21/02/2010• Solubility characteristics • Thermal properties • Excipient compatibility • Degradation mechanism • Structure elucidation CLS Landscape in Drug Development Attrition Rate * New Drug Development GAO-07-49 Nov 2006 Why compounds fail and slow down in development? Reasons for failure Safety issues Lack of efficacy Business cases Poor drug like properties Reasons for slowdown Spray drying and freeze drying are by far the most popular methods for drying protein solutions [16] Although the solid protein obtained from freeze drying has the advantage of storage stability it is not a direct particle formation method It requires a secondary procedure to break apart the cake into particles Spray drying is the most common powder generating method wherein a liquid feed

PHYSICO

21/02/2010• Solubility characteristics • Thermal properties • Excipient compatibility • Degradation mechanism • Structure elucidation CLS Landscape in Drug Development Attrition Rate * New Drug Development GAO-07-49 Nov 2006 Why compounds fail and slow down in development? Reasons for failure Safety issues Lack of efficacy Business cases Poor drug like properties Reasons for slowdown

Wood drying (also seasoning lumber or wood seasoning) reduces the moisture content of wood before its use When the drying is done in a kiln the product is known as kiln-dried timber or lumber whereas air drying is the more traditional method There are two main reasons for drying wood: Woodworking When wood is used as a construction material whether as a structural support in a building

Effect of Aging on Material Properties and Partial Discharge Characteristics of Insulating Pressboard Yongqiang Wang * Xia Zhang Xiaolei Jiang and Yunjia Wang Pressboard samples with different aging degrees were prepared to study the material and discharge characteristics of pressboards with a shielding electrode The step-up method was used for the subsequent experiment The partial

A study of thermal drying process A K Haghi* H Ghanadzadeh The University of Guilan P O Box 3756 Rasht Iran Received 8 November 2004 revised received 17 August 2005 accepted 10 September 2005 Different aspects of heat and water transfer through textiles are reviewed in this paper The study illustrates the impact of the heat transfer process on the moisture transfer processes

CHARACTERISTICS OF A SELF-DRYING ROOF' A degradation of critical physical and thermal properties Condren (1982) suggested that moisture limit data were needed to determine the necessity of installing vapor retarders in roofing systems Unfortunately this information is still not available Without it we choose to conservatively limit the winter uptake so that condensation under the

Drying characteristics in a jet‐spouted bed dryer The

Drying characteristics in a jet‐spouted bed dryer Drying characteristics in a jet‐spouted bed dryer Markowski A S 1992-10-01 00:00:00 A conical jet-spouted bed dryer with inert bodies was used for drying of animal blood plasma The effects of the operating conditions on the product properties final moisture content and throughput of the dryer were investigated

Drying experiments were conducted in Thermal Process Laboratory of the Research and Technology Centre of Energy The drying characteristics of tomato were studied at 38C 44C 52C 57C and 64C with three air flow rates of 1ms -1 2ms -1 and 3ms -1 The drying continues until samples' mass reaches a final moisture content of 11% Some different mathematical models available in the

Tandem drying (hybrid drying) includes different drying methods at different stages in order to increase energy efficiency thermal performance drying uniformity and quality enhancement (Xu et al 2004) An example of tandem drying is RF post-backing drying which was shown to avoid discolouration and flavour loss (Koral 2004)

In this research oilseed flax fibre is dried and drying characteristics were investigated After drying the physical properties of the fibre were tested and analysed The fibre was dried using three different drying methods namely microwave microwave-convection and microwave-vacuum environments Curve fitting with four empirical methods has been carried out to determine the drying

Thermal drying systems may produce a variety of forms of dry material including fine dust flakes small pellets or larger fragments depending on the type of thermal drying system used the characteristics of biosolids processed and the use intended for the product Thermal drying typically must be preceded by or done in conjunction with a dewatering process Thermal drying is usually

CHARACTERISTICS OF A SELF-DRYING ROOF' A degradation of critical physical and thermal properties Condren (1982) suggested that moisture limit data were needed to determine the necessity of installing vapor retarders in roofing systems Unfortunately this information is still not available Without it we choose to conservatively limit the winter uptake so that condensation under the

Date slices were dried with the three drying methods convective (60 70 and 80 C) microwave (120 W) and freeze drying to determine drying characteristics and to compare the dried fruit quality All colour parameters changed depending on the drying method and colours closest to the fresh sample were obtained with freeze drying It is interesting to note that the total phenolic content and

Structural Characteristics Thermal Degradation Behaviour and extracted manually from the plant stem using two conventional methods hand stripping (HS) and hand beating (HB) After drying the fibres were either left untreated or were treated with potassium hydroxide (KOH) and then characterised using chemical analysis scanning electron microscopy (SEM) thermogravimetry analysis and

DETERMINATION OF THERMAL AND PHYSICAL PROPERTIES OF

We aim to determine as thermal properties thermal conductivity and strength palmyra items And as physical properties we will determine the density and humidity of the elements of this material These characteristics are critical in assessing the quality of a material with respect to the mechanical comfort heat and mass But before describing

particularly for local companies Drying process can cause changes in food surface characteristics which lead to color changes Changes attributed to carotenoids and other pigments can also be caused by heat and oxidation during drying In particular higher drying temperatures and longer drying times were seen to facilitate greater pigment losses (Noor Aziah and Komathi 2009) The properties

Thermal properties are also dependent on the te mperature as well as the chemical composition and phys ical structure of food Some models have been developed to predict the thermal properties of foods Some of these mod els take into account the food composition and also assess a physical representation of the food under study However often the values es timated by these models have

thermal conductivity to the interior of the mate-rial short drying period and low energy consump- tion [14 15] while it also has other shortcomings Effect of different drying methods on drying characteristics colour and microstructure properties of mushroom NAZMI IZLI – ESREF ISIK Summary In this study the effects of microwave convective and microwave-convective drying treatments on

When a wet solid is subjected to thermal drying two processes occur simultaneously: 1 Transfer of energy (mostly as heat) from the surrounding environment to evaporate the surface moisture 2 Transfer of internal moisture to the surface of the solid and its subsequent evaporation due to process 1 The rate at which drying is accomplished is governed by the rate at which the two processes

Thermal VicatB/120 ISO 306 C 145 HDT/Ae 1 8MPa edgew 120*1*04/s=100 ISO 75 C 127 Thermal conductivity DIN52612 W/m C 0 2 Coef of Lin Therm Exp extr 23-80C DIN53752 1/C 7 00E-05 Ball pressure test 125 2C IEC335-1 - Passes Thermal Index Electrical Properties UL746B C 100 Thermal Index Mech prop with impact UL746B C 100